In previous study we characterized the oncogenic role of long non-coding RNA MALAT1 in esophageal squamous cell carcinoma (ESCC), but the detailed mechanism remains obscure.Here we identified glyoxalase 1 (GLO1) as the most possible executor of MALAT1 by microarray screening.GLO1 is responsible for degradation of cytotoxic methylglyoxal (MGO), whic
Abstract Conducting clinical trials in developing countries often presents significant ethical, organisational, cultural and infrastructural challenges to researchers, pharmaceutical companies, sponsors and regulatory bodies.Globally, these regions are under-represented in research, yet this population stands to gain more from research in these set
Y chromosomes across diverse species convergently evolve a gene-poor, heterochromatic organization enriched for duplicated genes, LTR retrotransposons, and satellite DNA.Sexual antagonism and a loss of recombination play major roles in the degeneration of young Y chromosomes.However, the processes shaping the evolution of mature, already degenerate
A 52-year-old man with a history of right nephrectomy for a nonfunctioning kidney, consults after 22 years for fever with right lower abdominal pain.Surgical exploration was thereafter performed and the right ureteral stump was removed pride empire bowling ball en bloc.Pathological examination of the right ureterectomy specimen revealed a significa
ABSTRACT Introduction: The aim of the present prospective-randomized study was to compare perioperative outcomes and complications of bipolar and monopolar TURBT for lateral wall-located non-muscle fg42 replica invasive bladder cancers (NMIBC) under obturator nerve block (ONB).Patients and Methods: 80 patients who underwent TURBT for lateral wall-l